| Identification | Back Directory | [Name]
N-(2'-(S)-hydroxyarachidoyl)-D-erythro-sphingosine | [CAS]
1246298-48-5 | [Synonyms]
20:0(2S-OH) Ceramide
N-(2'-(S)-hydroxyarachidoyl)-D-erythro-sphingosine
N-(2'-(S)-hydroxyarachidoyl)-D-erythro-sphingosine
N-(2'-(S)-HYDROXYARACHIDOYL)-D-ERYTHRO-SPHINGOSINE;20:0(2S-OH) CERAMIDE
Eicosanamide, 2-hydroxy-N-[(1S,2R,3E)-2-hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl]-, (2S)- | [Molecular Formula]
C38H75NO4 | [MOL File]
1246298-48-5.mol | [Molecular Weight]
610.01 |
| Hazard Information | Back Directory | [General Description]
Ceramides linked to 2-hydroxy fatty acids (hFA) are present in the surface epithelium of the skin. 20:0(2S-OH) Ceramide is a unique ceramide containing 20C long chain base fatty acid (arachidic acid)-with 2′-hydroxyl group in S configuration. | [Biochem/physiol Actions]
Hydroxy fatty acid (hFA)-sphingolipids help in formation and function of myelin. In addition, they also play a vital role in cell signaling, cell differentiation and apoptosis. In epidermis, hFA-ceramides aid in permeability barrier function. NAD(P)H-dependent enzyme, fatty acid 2-hydroxylase (FA2H) catalyzes the synthesis of hFA-ceramides. FA2H gene mutation leads to the development of neurological disorders such as leukodystrophy and spastic paraparesis in humans. hFA-ceramides help PM02734 (elisidepsin), an?antitumor drug to exhibit its activity. |
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