| Identification | Back Directory | [Name]
Desmosterol-d6 | [CAS]
1246298-67-8 | [Synonyms]
Desmosterol-d6
[2H6]-Desmosterol
24-dehydro Cholesterol-d6
cholesta-5,24-dien-3-ol-d6
cholesta-5,24-dien-3β-ol-d6
Desmosterol-26,26,26,27,27,27-d6
CHOLESTA-5,24-DIEN-3-OL-D6;DESMOSTEROL-D6 | [Molecular Formula]
C27H44O | [MDL Number]
MFCD22416725 | [MOL File]
1246298-67-8.mol | [Molecular Weight]
384.638 |
| Chemical Properties | Back Directory | [Melting point ]
114-116°C | [storage temp. ]
Refrigerator | [solubility ]
Chloroform (Slightly), Methanol (Slightly, Sonicated) | [form ]
Solid | [color ]
Off-White to Light Beige |
| Hazard Information | Back Directory | [Description]
24-dehydro Cholesterol-d6 is intended for use as an internal standard for the quantification of 24-dehydro cholesterol by GC- or LC-MS. 24-dehydro Cholesterol is an immediate precursor to cholesterol in the Bloch pathway of cholesterol biosynthesis. Structurally, it varies from cholesterol only by a single double bond at carbon 24 and has been used as cholesterol substitute in cellular membrane studies. During brain development, 24-dehydro cholesterol transiently accumulates, composing up to 30% of total brain sterol, where it is poised to rapidly enrich membrane sterols. However, defects in cholesterol synthesis can lead to a condition called desmosterolosis, which results in an accumulation of excess 24-dehydro cholesterol. 24-dehydro Cholesterol has been reported to activate liver X receptor-target genes in both the liver of cholesterol-free mice and in cholesterol-starved macrophage foam cells in atherosclerotic lesions. | [Uses]
A labelled metabolite of Cholesterol (C432501). |
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Energy Chemical
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http://www.energy-chemical.com |
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Pharma Affiliates
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172-5066494 |
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https://www.chemicalbook.com/ShowSupplierProductsList694812/0.htm |
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