| Identification | Back Directory | [Name]
4-Hydroxy Cholesterol-d7 | [CAS]
1246302-80-6 | [Synonyms]
4-Hydroxy Cholesterol-d7
cholest-5-ene-3,4-diol-d7
4β-Hydroxy Cholesterol-d7
2H7]-4β-Hydroxycholesterol
4-beta-Hydroxy Cholesterol-d7
CHOLEST-5-ENE-3,4-DIOL-D7;4-HYDROXYCHOLESTEROL-D7
(3S,4R,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6,7,7,7-tetradeuterio-6-(trideuteriomethyl)heptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-3,4-diol | [Molecular Formula]
C27H46O2 | [MDL Number]
MFCD15071187 | [MOL File]
1246302-80-6.mol | [Molecular Weight]
402.653 |
| Chemical Properties | Back Directory | [Melting point ]
154-159°C | [storage temp. ]
-20°C | [solubility ]
Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly, Heated) | [form ]
Solid | [color ]
White to Off-White |
| Hazard Information | Back Directory | [Chemical Properties]
White Solid | [Uses]
4β-Hydroxy Cholesterol-d7 is a labelled metabolite of Cholesterol. It is formed from Cholesterol by the drug-metabolizing enzyme cytochrome P 450 3A4. A potential ligand for the nuclear receptor LXR and also a new endogenous CYP3A marker. | [Uses]
4β-hydroxycholesterol-d7 has been used:
- as an internal standard to spike plasma samples ultra-high-pressure liquid,chromatography–tandem mass spectrometry (UHPLC-MS/MS) analysis
- to spike serum samples for mass spectrometry measurements
- as an internal standard for the quantification of human colon biopsies samples using HPLC-MS
| [General Description]
4β-hydroxycholesterol (4β-HC) is a catabolic product of cholesterol metabolism mediated by the enzyme cytochrome P450 family 3 subfamily A member 4 (CYP3A4). 4β-hydroxycholesterol-d7 is the deuterated form of 4β-hydroxycholesterol. | [Biochem/physiol Actions]
4β-hydroxycholesterol (4β-HC) may function as a liver X receptor ligand. The levels of 4β-HC are elevated in dextran sulfate induced colitis along with other oxysterols and it may promote colon inflammation. |
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Sigma-Aldrich
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021-61415566 800-8193336 |
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https://www.sigmaaldrich.cn |
| Company Name: |
Energy Chemical
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021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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