| Identification | Back Directory | [Name]
Sotalol D6 HCl | [CAS]
1246820-85-8 | [Synonyms]
Sotalol D6 HCl
[2H6]-Sotalol HCl
[2H6]- Sotalol Hydrochloride
(±)-Sotalol-d6 hydrochloride (dimethyl-d6) | [Molecular Formula]
C12H15ClD6N2O3S | [MDL Number]
MFCD04972578 | [MOL File]
1246820-85-8.mol | [Molecular Weight]
314.862 |
| Hazard Information | Back Directory | [Description]
Sotalol-d6 is intended for use as an internal standard for the quantification of sotalol by GC- or LC-MS. Sotalol is a non-selective antagonist of β-adrenergic receptors (β-ARs; IC50s = 8.9 and 5.2 μM for β1- and β2-ARs, respectively) and a class III antiarrhythmic agent. It decreases delayed outward potassium currents (IK) in guinea pig ventricular cells and prolongs action potential duration in electrically stimulated isolated guinea pig papillary muscles when used at a concentration of 100 μM. Sotalol decreases heart rate and increases blood pressure and the cardiac functional refractory period (FRP) in a canine model of ventricular tachycardia induced by programmed electrical stimulation (PES). Formulations containing sotalol have been used in the treatment of ventricular arrhythmias and maintenance of normal sinus rhythm in patients with atrial fibrillation or flutter (AFIB/AFL). | [Uses]
A labelled potent α-adrenergic receptor antagonist. A class III antiarrythmic. It has been shown to prolong action potential and increases the refractory period. |
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| Company Name: |
Energy Chemical
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021-58432009 400-005-6266 |
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http://www.energy-chemical.com |
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4008-099-669 |
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https://www.chemicalbook.com/ShowSupplierProductsList112975/0.htm |
| Company Name: |
MedChemExpress
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021-58955995 |
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www.medchemexpress.com |
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