| Identification | Back Directory | [Name]
FGTI-2734 | [CAS]
1247018-19-4 | [Synonyms]
FGTI-2734
2-Pyridinesulfonamide, N-[2-[(4-cyano-2-fluorophenyl)[(1-methyl-1H-imidazol-5-yl)methyl]amino]ethyl]-N-(cyclohexylmethyl)- | [Molecular Formula]
C26H31FN6O2S | [MDL Number]
MFCD32174296 | [MOL File]
1247018-19-4.mol | [Molecular Weight]
510.63 |
| Chemical Properties | Back Directory | [Boiling point ]
770.1±70.0 °C(Predicted) | [density ]
1.28±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO:50.0(Max Conc. mg/mL);97.92(Max Conc. mM) | [form ]
Solid | [pka]
6.60±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
FGTI-2734 is a RAS C-terminal mimetic dual farnesyl transferase (FT) and geranylgeranyl transferase-1 (GGT-1) inhibitor. It can prevent membrane localization of KRAS, hence solving KRAS resistance problem and thwarting mutant KRAS patient-derived pancreatic tumors. | [target]
FGTI-2734 is a RAS C-terminal mimetic dual farnesyl transferase (FT) and geranylgeranyl transferase-1 (GGT-1) inhibitor with IC50s of 250 nM and 520 nM for FT and GGT-1, respectively. |
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| Company Name: |
DC Chemicals
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| Tel: |
021-58447131 13564518121 |
| Website: |
https://www.chemicalbook.com/ShowSupplierProductsList927327/0.htm |
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