| Identification | Back Directory | [Name]
tridihexethyl iodide | [CAS]
125-99-5 | [Synonyms]
Tridihexethl
Tridihexethyl
tridihexethyl iodide | [EINECS(EC#)]
204-762-7 | [Molecular Formula]
C21H36NO.I | [MDL Number]
MFCD00137404 | [MOL File]
125-99-5.mol | [Molecular Weight]
445.421 |
| Hazard Information | Back Directory | [Originator]
Pathilon,Burroughs-Wellcome,US,1955 | [Definition]
ChEBI: Tridihexethyl iodide is an organic iodide salt. It contains a tridihexethyl. | [Manufacturing Process]
Acetophenone, paraformaldehyde and diethylamine are first reacted to give ω-
diethylaminopropiophenone. That is reacted with cyclohexylmagnesium
bromide to give 3-diethylamino-1-cyclohexyl-1-phenylpropanol-1.
To 1,320 parts of methyl isobutyl ketone is added 570 parts of 3-
diethylamino-1-cyclohexyl-1-phenylpropanol-1 (2 mols) and the mixture is
stirred until solution is complete. Then 500 parts (3.2 molsor 60% excess) of
ethyl iodide are added. After filtration, the filtrate is diluted with an additional
300 parts of methyl isobutyl ketone and the solution is then heated at the
reflux temperature (108°C to 110°C) for 9 hours. After cooling to 0°C, the
precipitated solid material is removed by filtration, washed with isopropyl
acetate and dried. Approximately 777 parts of product is obtained or a yield of 88.6% based on as-is starting material or 92.5% based on real starting
material. | [Therapeutic Function]
Anticholinergic |
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