| Identification | Back Directory | [Name]
CP21R7(CP21) | [CAS]
125314-13-8 | [Synonyms]
CP21R7
CS-2352
CP21R7(CP21)
CP21 (CP21R7)
3-(3-aminophenyl)-4-(1-methyl-3-indolyl)-1H-pyrrole-2,5-dione
3-(3-Aminophenyl)-4-(1-methyl-1H-indol-3-yl)pyrrole-2,5-dione
3-(3-aminophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
1H-Pyrrole-2,5-dione, 3-(3-aminophenyl)-4-(1-methyl-1H-indol-3-yl)- | [Molecular Formula]
C19H15N3O2 | [MDL Number]
MFCD30343845 | [MOL File]
125314-13-8.mol | [Molecular Weight]
317.34 |
| Chemical Properties | Back Directory | [Boiling point ]
627.4±55.0 °C(Predicted) | [density ]
1.37±0.1 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C | [solubility ]
insoluble in EtOH; insoluble in H2O; ≥14.25 mg/mL in DMSO | [form ]
crystalline solid | [pka]
7.79±0.60(Predicted) | [color ]
Yellow to orange |
| Hazard Information | Back Directory | [Uses]
CP21R7 is a potent and selective inhibitor of GSK3β. | [Biological Activity]
cp21r7 is a potent and selective inhibitor of gsk3β.the glycogen synthase kinase-3β (gsk-3β), a serine/threonine, is a ubiquitous kinase that participates in a multitude of cellular processes, such as cell membrane-to-nucleus signaling, gene transcription, translation, cytoskeletal structuring and cell cycle progression and survival [1]. | [in vitro]
cp21r7 was an inhibitor of gsk3β and pkcα with the ic50 values of 1.8 and 1900 nm, respectively [1]. in the human reporter cell line, cp21r7 potently activated canonical wnt signallingeven at the dose of 1 μm, with highest activity seen at 3 μm [2]. in human ipscs exposed to n2b27 medium, supplemented with 1 μm gsk3β inhibitor cp21r7 strongly upregulated the expression of t (also known as brachyury, t/bry), a meso-endoderm marker expressed in the primitive streak [2]. | [References]
[1] gong l, hirschfeld d, tan y c, et al. discovery of potent and bioavailable gsk-3β inhibitors[j]. bioorganic & medicinal chemistry letters, 2010, 20(5): 1693-1696.
[2] ciampi o, iacone r, longaretti l, et al. generation of functional podocytes from human induced pluripotent stem cells[j]. stem cell research, 2016, 17(1): 130-139. |
|
|