| Identification | Back Directory | [Name]
Aripiprazole Lauroxil | [CAS]
1259305-29-7 | [Synonyms]
RDC 3317
1259305-29-7.
Aripiprazole Lauroxil
Dodecanoic acid [7-[4-[4-(2,3-dichlorophenyl)-1-piperazinyl]butoxy]-3,4-dihydro-2-oxo-1(2H)-quinolinyl]methyl ester | [EINECS(EC#)]
826-270-7 | [Molecular Formula]
C36H51Cl2N3O4 | [MDL Number]
MFCD26967976 | [MOL File]
1259305-29-7.mol | [Molecular Weight]
660.71 |
| Chemical Properties | Back Directory | [Melting point ]
83 - 84°C | [Boiling point ]
781.7±60.0 °C(Predicted) | [density ]
1.153±0.06 g/cm3(Predicted) | [storage temp. ]
Refrigerator, under inert atmosphere | [solubility ]
Chloroform (Slightly), Methanol (Slightly, Sonicated) | [form ]
Solid | [pka]
7.67±0.10(Predicted) | [color ]
White to Off-White |
| Hazard Information | Back Directory | [Description]
Aripiprazole
lauroxil is a long acting injectable (LAI) pro-drug formulation
of aripiprazole approved in the U.S. for the treatment of
schizophrenia. Aripiprazole lauroxil is a dopamine D2
receptor partial antagonist, a 5-HT2A antagonist, and a 5-
HT1A partial agonist that was developed by Alkermes. It was Aripiprazole
lauroxil is a long acting injectable (LAI) pro-drug formulation
of aripiprazole approved in the U.S. for the treatment of
schizophrenia.28 Aripiprazole lauroxil is a dopamine D2
receptor partial antagonist, a 5-HT2A antagonist, and a 5-
HT1A partial agonist that was developed by Alkermes. It was | [Definition]
ChEBI: A dodecanoate ester obtained by formal condensation of the carboxy group of dodecanoic acid with the hydroxy group of 7-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}-2-oxo-3,4-dihydroquinolin-1(2H)-yl]methanol. A prodrug for aripipraz
le, it is used for treatment of schizophrenia. | [Synthesis]
The synthesis of aripiprazole lauroxil has only been described
on gram scale in the patent literature. Commercially available aripiprazole (58) was
treated with formaldehyde to give hemiaminal 59 in 65% crude
yield and was then heated with lauric anhydride to give
aripiprazole lauroxil (VII) in 21% overall yield.
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