| Identification | Back Directory | [Name]
Donepezil-d7 hydrochloride | [CAS]
1261394-20-0 | [Synonyms]
Donepezil hydrochloride salt
[2H7]-Donepezil Hydrochloride
2-[[1-[dideuterio-(2,3,4,5,6-pentadeuteriophenyl)methyl]piperidin-4-yl]methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one:hydrochloride
Donepezil D7 HydrochlorideQ: What is
Donepezil D7 Hydrochloride Q: What is the CAS Number of
Donepezil D7 Hydrochloride Q: What is the storage condition of
Donepezil D7 Hydrochloride Q: What are the applications of
Donepezil D7 Hydrochloride | [Molecular Formula]
C24H23ClD7NO3 | [MDL Number]
MFCD28138973 | [MOL File]
1261394-20-0.mol | [Molecular Weight]
422.996 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [color ]
Pale Yellow | [Stability:]
Hygroscopic |
| Hazard Information | Back Directory | [Uses]
A labelled nootropic. An inhibitor of acetylcholinesterase. | [Biological Activity]
Donepezil-d7 (hydrochloride) (E2020-d7) is the deuterium labeled Donepezil. Donepezil (E2020 free base) is a specific and potent AChE inhibitor with IC50s of 8.12 nM and 11.6 nM for bovine AChE and human AChE, respectively[1].
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1]. | [References]
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
[2]. Ogura, H., et al., Comparison of inhibitory activities of donepezil and other cholinesterase inhibitors on acetylcholinesterase and butyrylcholinesterase in vitro. Methods Find Exp Clin Pharmacol, 2000. 22(8): p. 609-13.;Snape, M.F., et al., A comparative study in rats of the in vitro and in vivo pharmacology of the acetylcholinesterase inhibitors tacrine, donepezil and NXX-066. Neuropharmacology, 1999. 38(1): p. 181-93.;Huang, Z.H., et al., Donepezil protects endothelial cells against hydrogen peroxide-induced cell injury. CNS Neurosci Ther, 2012. 18(2): p. 185-7. |
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Energy Chemical
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