| Identification | Back Directory | [Name]
Benzamide, N-[[[3-(benzoylamino)phenyl]amino]iminomethyl]-3,4,5-trimethoxy- | [CAS]
1263131-83-4 | [Synonyms]
MRT-14
Benzamide, N-[[[3-(benzoylamino)phenyl]amino]iminomethyl]-3,4,5-trimethoxy- | [Molecular Formula]
C24H24N4O5 | [MOL File]
1263131-83-4.mol | [Molecular Weight]
448.47 |
| Chemical Properties | Back Directory | [density ]
1.26±0.1 g/cm3(Predicted) | [storage temp. ]
4°C, protect from light | [solubility ]
DMSO : 100 mg/mL (222.98 mM; Need ultrasonic) | [form ]
Solid | [pka]
10.28±0.46(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Biological Activity]
MRT-14 is a potent antagonist of Smo. Smo is the major component involved in signal transduction of the Hedgehog (Hh) morphogens. MRT-14 has the potential for the research of several types of cancers linked to abnormal Hh signaling[1]. | [References]
[1]. Manetti F, et al. Virtual screening-based discovery and mechanistic characterization of the acylthiourea MRT-10 family as smoothened antagonists. Mol Pharmacol. 2010;78(4):658-665. |
|
|