| Identification | Back Directory | [Name]
SR 12813 | [CAS]
126411-39-0 | [Synonyms]
GW485801
GW-485801
GW 485801
SR12813;SR 12813
SR-12813(GW 485801)
SR-12813;SR12813;SR 12813;GW 485801;GW-485801;GW485801
[[3,5-Bis(1,1-dimethylethyl)-4-hydroxyphenyl]ethenylidene]bis-phosphonicacidtetraethylester
Phosphonic acid, P,P'-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]ethenylidene]bis-, P,P,P',P'-tetraethyl ester | [Molecular Formula]
C24H42O7P2 | [MDL Number]
MFCD00888473 | [MOL File]
126411-39-0.mol | [Molecular Weight]
504.53 |
| Chemical Properties | Back Directory | [Melting point ]
119-121℃ | [Boiling point ]
552.6±50.0 °C(Predicted) | [density ]
1.117±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
DMSO: ≥10 mg/mL
| [form ]
solid
| [pka]
9.95±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
SR 12813 is a pregnane X receptor (PXR, NR 112) agonist. | [Definition]
ChEBI: An organic phosphonate that is the tetraethyl ester of [2-(3,5-di-tert-butyl-4-hydroxyphenyl)ethene-1,1-diyl]bis(phosphonic acid). | [Biological Activity]
Pregnane X receptor (PXR) agonist (EC 50 values are 200 and 700 nM for human and rabbit PXR respectively). Activates the farnesoid X receptor (FXR) at μ M concentrations. Displays hypocholesterolaemic activity via enchanced degradation of HMG-CoA reductase. | [Biochem/physiol Actions]
SR-12813 is a 1,1-bisphosphonate ester that exhibits hypocholesterolemic activity. It decreases the biosynthesis of cholesterol by enhancing the degradation of HMG-CoA reductase. | [storage]
Store at +4°C |
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BOC Sciences
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1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
| Company Name: |
Sigma-Aldrich
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021-61415566 800-8193336 |
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https://www.sigmaaldrich.cn |
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