| Identification | Back Directory | [Name]
siomycin A | [CAS]
12656-09-6 | [Synonyms]
siomycin A
Mutabilycin
Mutabillicin
Antibiotic 6741-21
AKFVOKPQHFBYCA-OFENGFFDSA-N
Mutabilycin, SporangioMycin, 6741-21, Mutabillicin
Alaninamide, N-[(7R,8S)-2-carboxy-7,8-dihydro-8-hydroxy-4-[(1S)-1-hydroxyethyl]-7-quinolinyl]-L-valyl-2,3-didehydroalanyl-2,3-didehydroalanyl-L-alanyl-2-[(4aR,11S,14Z,18S,21S,28S,32aS)-4a-amino-21-[(1S,2R)-1,2-dihydroxy-1-methylpropyl]-14-ethylidene-3,4,4a,9,10,11,12,13,14,18,19,20,21,27,28,32a-hexa... | [Molecular Formula]
C71H81N19O18S5 | [MOL File]
12656-09-6.mol | [Molecular Weight]
1648.84 |
| Chemical Properties | Back Directory | [density ]
1.65±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
DMSO: complete10 mg/ml, clear, colorless to faintly yellow | [form ]
White solid. | [pka]
10.43±0.46(Predicted) |
| Hazard Information | Back Directory | [Uses]
Siomycin is a macrocyclic antibiotic with potent and selective antibacterial activity discovered in 1969. Siomycin is a potent inhibitor of the oncogenic transcription factor, FoxM1. The reduced transcription activity is reflected in the down regulation of protein and mRNA levels of FoxM1 and effects on down stream genes, Cdc25B, survivin and CENPB. In vitro, siomycin inhibits FoxM1-induced cell growth on soft agar and selectively kill transformed but not normal cells. |
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