| Identification | Back Directory | [Name]
cinacalcet iMpurity 8 | [CAS]
1271930-15-4 | [Synonyms]
Cinacalcet USP RC B
CicalcetImpurityDHCl
CicalcetImpurity1HCl
cinacalcet iMpurity 8
Cinacalcet Impurity D HCL
Cinacalcet tertiary amine
Cinacalcet Hydrochloride iMpuritX
Cinacalcet USP Related Compound B
Cinacalcet Impurity 5(Cinacalcet USP RC B)
N-[(3-Trifluoromethyl)phenyl)propyl] Cinacalcet
Cinacalcet Related Compund B (Cinacalcet Impurity D)
"(R)-N-(1-(naphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl)phenyl)
[(1R)-1-(naphthalen-1-yl)ethyl]bis({3-[3-(trifluoromethyl)phenyl]propyl})amine
1-NaphthaleneMethanaMine, α-Methyl-N,N-bis[3-[3-(trifluoroMethyl)phenyl]propyl]-, (αR)-
(R)-N-(1-(naphthalen-1-yl)ethyl)-3-(2-(trifluoromethyl)phenyl)propan-1-amine hydrochloride
(R)-(1-naphthalen-1-ylethyl)-N,N-bis[3-(3-trifluoromethylphenyl)propyl]amine, hydrogen chloride
N-[(1R)-1-naphthalen-1-ylethyl]-3-[3-(trifluoromethyl)phenyl]-N-[3-[3-(trifluoromethyl)phenyl]propyl]propan-1-amine
(R)-N-(1-(naphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl)phenyl)-N-(3-(3-(trifluoromethyl)phenyl)propyl)propan-1-amine
Cinacalcet impurity 20/(R)-N-(1-(naphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl)phenyl)-N-(3-(3-(trifluoromethyl)phenyl)propyl)propan-1-amine hydrochloride
Cinacalcet Impurity DQ: What is
Cinacalcet Impurity D Q: What is the CAS Number of
Cinacalcet Impurity D Q: What is the storage condition of
Cinacalcet Impurity D Q: What are the applications of
Cinacalcet Impurity D | [Molecular Formula]
C32H31F6N | [MDL Number]
MFCD27980107 | [MOL File]
1271930-15-4.mol | [Molecular Weight]
543.59 |
| Chemical Properties | Back Directory | [Boiling point ]
552.2±50.0 °C(Predicted) | [density ]
1.203±0.06 g/cm3(Predicted) | [pka]
8.40±0.50(Predicted) | [InChIKey]
BMWNEBVDXWCUKG-CRPMJUFNNA-N | [SMILES]
C(N([C@@H](C1=C2C(C=CC=C2)=CC=C1)C)CCCC1=CC=CC(C(F)(F)F)=C1)CCC1=CC=CC(C(F)(F)F)=C1 |&1:2,r| |
| Hazard Information | Back Directory | [Description]
Cinacalcet Impurity D is a potential byproduct or impurity in the synthesis of the drug. It is essential to study the properties and potential implications of Cinacalcet Impurity D for pharmaceutical research. Cinacalcet is a drug commonly used for the treatment of hyperparathyroidism in patients with chronic kidney disease. | [Uses]
N-[(3-Trifluoromethyl)phenyl)propyl] Cinacalcet (Cinacalcet USP Related Compound B) is an impurity of Cinacalcet Hydrochloride (C441800). Cinacalcet is used in clinical trial in secondary hyperparathyroidism. | [Preparation]
Cinacalcet hydrochloride (11 g, 0.028 mol) in toluene (150 mL) was added to potassium carbonate (7.74 g, 0.056 mol) followed by 1-(3-bromopropyl)-3-(trifluoromethyl)benzene (14.95 g, 0.056 mol) under stirring at 25-30 °C. The reaction was heated and stirred at 110-111 °C for 48 h. Upon completion of the reaction (by TLC), the reaction was cooled and quenched with water (100 mL). The organic layer was separated, washed with water (100 mL), and concentrated under reduced pressure to obtain a thick oil. The crude oil was then purified by column chromatography on silica gel by eluting with chloroform to afford Cinacalcet Impurity D as a thick transparent oil.  |
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Roark Standards
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0755-83552066 15986688328 |
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roarkstandards.com |
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