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ChemicalBook--->CAS DataBase List--->127308-98-9

127308-98-9

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127308-98-9 Structure

127308-98-9 Structure
IdentificationBack Directory
[Name]

Zamifenacinfumarate
[CAS]

127308-98-9
[Synonyms]

UK-76654 fumarate
Zamifenacinfumarate
(3R)-1-[2-(1-,3-Benzodioxol-5-yl)ethyl]-3-(diphenylmethoxy)piperidinefumarate
[Molecular Formula]

C27H29NO3.C4H4O4
[MDL Number]

MFCD09263617
[MOL File]

127308-98-9.mol
[Molecular Weight]

531.602
Chemical PropertiesBack Directory
[storage temp. ]

Inert atmosphere,2-8°C
[solubility ]

Soluble to 100 mM in DMSO and to 25 mM in ethanol
[form ]

Powder
[color ]

White to off-white
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319-H335
[Precautionary statements ]

P261-P305+P351+P338
Hazard InformationBack Directory
[Uses]

Zamifenacin Fumarate is a selective antagonist of mAChR M3 (M3 muscarinic receptor).
[Biological Activity]

Selective M 3 muscarinic receptor antagonist (pK i values are 8.52, 7.93, 7.90 and 7.78 for M 3 , M 2 , M 1 and M 4 receptors respectively). Displays higher affinity at ileal M 3 receptors (pK i = 9.3) compared to oesophageal and tracheal M 3 receptors (pK i values are 8.8 and 8.2 respectively). In vivo, inhibits gastrointestinal motility in the absence of cardiovascular effects.
Spectrum DetailBack Directory
[Spectrum Detail]

Zamifenacinfumarate(127308-98-9)1HNMR
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