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127716-49-8

127716-49-8 Structure

127716-49-8 Structure
IdentificationBack Directory
[Name]

(+/-)5(6)-EPOXY-8Z,11Z,14Z,17Z-EICOSATETRAENOIC ACID, METHYL ESTER
[CAS]

127716-49-8
[Synonyms]

5(6)-EPETE METHYL ESTER
BDSCYYACNUKQLZ-AECQIINDSA-N
5,6-EPOXY EICOSATETRAENOIC ACID METHYL ESTER
(+/-)5(6)-EPOXY-8Z,11Z,14Z,17Z-EICOSATETRAENOIC ACID, METHYL ESTER
(+/-)5(6)-EPOXY-8Z,11Z,14Z,17Z-EICOSATETRAENOIC ACID, METHYL ESTER
2-Oxiranebutanoic acid, 3-(2Z,5Z,8Z,11Z)-2,5,8,11-tetradecatetraen-1-yl-, methyl ester, (2R,3S)-rel-
[Molecular Formula]

C21H32O3
[MDL Number]

MFCD02259377
[MOL File]

127716-49-8.mol
[Molecular Weight]

332.48
Chemical PropertiesBack Directory
[solubility ]

DMF: 10 mg/ml; DMSO: 20 mg/ml; Ethanol: 20 mg/ml; Ethanol:PBS (pH 7.2)(1:1): 500 μg/ml
Safety DataBack Directory
[Symbol(GHS) ]


GHS02,GHS07
[Signal word ]

Danger
[Hazard statements ]

H225-H319
[Precautionary statements ]

P210-P233-P240-P241-P242-P243-P264-P280-P303+P361+P353-P305+P351+P338-P337+P313-P370+P378-P403+P235-P501
Hazard InformationBack Directory
[Description]

(±)5(6)-EpETE methyl ester is a derivative of 5(6)-EpETE which is stable enough to ship and handle routinely.(±) 5(6)-EpETE methyl ester is a chemically less reactive derivative of 5(6)-EpETE. The active free acid can be generated from the methyl ester by careful base hydrolysis. Epoxy eicosatetraenoic acids (EpETEs) are the epoxygenase metabolites of EPA. A number of vicinal diol metabolites of EpETEs have been detected in the plasma of patients on marine oil dietary supplementation, while in subjects on a typical western diet these compounds are generally not detected.1 The specific biologic activity of 5(6)-EpETE and its methyl ester have not been documented.
[References]

1. Knapp, H.R., Miller, A.J., and Lawson, J.A. Urinary excretion of diols derived from eicosapentaenoic acid during N-3 fatty acid ingestion Prostaglandins 42,47-53(1991).
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