128007-31-8

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128007-31-8 Structure

Identification	Back Directory
[Name] ARVANIL
[CAS] 128007-31-8
[Synonyms] ARVANIL N-VANILLYLARACHIDONAMIDE N-[(4-HYDROXY-3-METHOXYPHENYL)METHYL]-5Z,8Z,11Z,14Z-EICOSATETRAENAMIDE 14-eicosatetraenamide,n-((4-hydroxy-3-methoxyphenyl)methyl)-(all-z)-11 11,14-eicosatetraenamide(all-z)-n-((4-hydroxy-3-methoxyphenyl)methyl)-8 (5Z,8Z,11Z,14Z)-N-[(4-Hydroxy-3-methoxyphenyl)methyl]-5,8,11,14-Eicosatetraenamide
[Molecular Formula] C28H41NO3
[MDL Number] MFCD01752675
[MOL File] 128007-31-8.mol
[Molecular Weight] 439.63

Chemical Properties	Back Directory
[Boiling point ] 619.4±55.0 °C(Predicted)
[density ] 1.002±0.06 g/cm3(Predicted)
[Fp ] 14℃
[storage temp. ] -20°C
[solubility ] Soluble in ethanol (supplied pre-dissolved in anhydrous ethanol, 5mg/ml)
[form ] liquid
[pka] 9.76±0.20(Predicted)
[color ] colorless to pale yellow

Hazard Information	Back Directory
[Uses] Arvanil is a cannabinoid CB1?and vanilloid TRPV1 (VR) agonist.
[Definition] ChEBI: N-arachidonoyl vanillylamine is a member of phenols and a member of methoxybenzenes.
[Biological Activity] Cannabinoid CB 1 and vanilloid TRPV1 (VR1) agonist (K i values are 0.5 and 0.3 μ M respectively). Also inhibits the anandamide transporter (IC 50 = 3.6 μ M). Analgesic, vasodilatory and anti-inflammatory in vivo .
[Biochem/physiol Actions] Arvanil is an activator of cannabinoid and vanilloid receptors, and a potent inhibitor of anandamide accumulation. Arvanil inhibits growth of astrocytoma xenograft tumors in mice, mimicing the effect of neural precursor cells, that have been shown to kill TRPV1-expressing tumor cells by secreting endovanilloids.
[storage] Desiccate at -20°C

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