| Identification | Back Directory | [Name]
ARVANIL | [CAS]
128007-31-8 | [Synonyms]
ARVANIL
N-VANILLYLARACHIDONAMIDE
N-[(4-HYDROXY-3-METHOXYPHENYL)METHYL]-5Z,8Z,11Z,14Z-EICOSATETRAENAMIDE
14-eicosatetraenamide,n-((4-hydroxy-3-methoxyphenyl)methyl)-(all-z)-11
11,14-eicosatetraenamide(all-z)-n-((4-hydroxy-3-methoxyphenyl)methyl)-8
(5Z,8Z,11Z,14Z)-N-[(4-Hydroxy-3-methoxyphenyl)methyl]-5,8,11,14-Eicosatetraenamide | [Molecular Formula]
C28H41NO3 | [MDL Number]
MFCD01752675 | [MOL File]
128007-31-8.mol | [Molecular Weight]
439.63 |
| Chemical Properties | Back Directory | [Fp ]
14℃ | [storage temp. ]
-20°C | [solubility ]
Soluble in ethanol (supplied pre-dissolved in anhydrous ethanol, 5mg/ml) | [form ]
liquid | [color ]
colorless to pale yellow |
| Hazard Information | Back Directory | [Uses]
Arvanil is a cannabinoid CB1?and vanilloid TRPV1 (VR) agonist. | [Definition]
ChEBI: N-arachidonoyl vanillylamine is a member of phenols and a member of methoxybenzenes. | [Biological Activity]
Cannabinoid CB 1 and vanilloid TRPV1 (VR1) agonist (K i values are 0.5 and 0.3 μ M respectively). Also inhibits the anandamide transporter (IC 50 = 3.6 μ M). Analgesic, vasodilatory and anti-inflammatory in vivo . | [Biochem/physiol Actions]
Arvanil is an activator of cannabinoid and vanilloid receptors, and a potent inhibitor of anandamide accumulation. Arvanil inhibits growth of astrocytoma xenograft tumors in mice, mimicing the effect of neural precursor cells, that have been shown to kill TRPV1-expressing tumor cells by secreting endovanilloids. | [storage]
Desiccate at -20°C |
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