ChemicalBook--->CAS DataBase List--->128446-33-3

128446-33-3

128446-33-3 Structure

128446-33-3 Structure
IdentificationBack Directory
[Name]

2-hydroxypropyl-α-cyclodextrin
[CAS]

128446-33-3
[Synonyms]

HPACD
Cavasol? W6 HP
2-hydroxypropyl-α-cyclodextrin
Hydroxpropyl Alpha Cyclodextrim
(2-Hydroxyethyl)-a-cyclodextrin
(2-Hydroxypropyl)-a-cyclodextrin
HYDROXYPROPYL-ALPHA-CYCLODEXTRIN, MS=0.6
.alpha.-Cyclodextrin, 2-hydroxypropyl ethers
(2-Hydroxypropyl)-alpha-cyclodextrin average Mw ~1,180
[EINECS(EC#)]

451-510-9
[MDL Number]

MFCD00197866
Chemical PropertiesBack Directory
[Melting point ]

245 °C (dec.)(lit.)
[density ]

1.39 at 24.6℃
[solubility ]

Soluble in water, methanol, DMF. Insoluble in acetone, chloroform.
[form ]

Solid powder
[color ]

White to off white
[optical activity]

[α]20/D +125°, c = 1 in H2O
[LogP]

-10.6--9.89
[Surface tension]

66.1mN/m at 1g/L and 20℃
[EPA Substance Registry System]

.alpha.-Cyclodextrin, 2-hydroxypropyl ethers (128446-33-3)
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H319
[Precautionary statements ]

P264-P280-P305+P351+P338-P337+P313P
[WGK Germany ]

3
Hazard InformationBack Directory
[Uses]

  • (2-Hydroxypropyl)-α-cyclodextrin can be used as a chiral selector to resolve tryptophan racemate by capillary electrophoresis.
  • It can be used to synthesize biodegradable polyrotaxanes for fabricating blood-contacting devices.
  • Co-polymer based on (2-hydroxypropyl)-α-cyclodextrin cross-linked with polyethylenimine can be used as a gene delivery vector.
  • It can also be used as stabilizer for antibacterial iodine formulations, as it forms a stable inclusion complex with iodine and improves aqueous solubility.

[General Description]

(2-Hydroxypropyl)-α-cyclodextrin is a hydroxyalkyl derivative of cyclodextrin, which is generally used as a substitute of α-cyclodextrin for potential application in food, cosmetics and pharmaceutical industries. It may be used as a parenteral drug carrier on account of its attractive characteristics such as: a greater extent of solubility in water, high dissolution capacity for weakly soluble analytes, and low toxicity.
Spectrum DetailBack Directory
[Spectrum Detail]

2-hydroxypropyl-α-cyclodextrin(128446-33-3)Raman
2-hydroxypropyl-α-cyclodextrin(128446-33-3)IR
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