| Identification | Back Directory | [Name]
BI-99179 | [CAS]
1291779-76-4 | [Synonyms]
BI-99179
BI-99179
(BI99179)
(1R,3S)-N-[4-(1,3-benzoxazol-2-yl)phenyl]-N-methyl-3-(propanoylamino)cyclopentane-1-carboxamide
Cyclopentanecarboxamide, N-[4-(2-benzoxazolyl)phenyl]-N-methyl-3-[(1-oxopropyl)amino]-, (1R,3S)- | [Molecular Formula]
C23H25N3O3 | [MDL Number]
MFCD25976795 | [MOL File]
1291779-76-4.mol | [Molecular Weight]
391.46 |
| Chemical Properties | Back Directory | [Boiling point ]
603.1±55.0 °C(Predicted) | [density ]
1.25±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
15.72±0.40(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Biochem/physiol Actions]
BI 99179 is a non-cytotoxic (by LDH release; 30 μM, U937) orally available, brain-penetrant, highly potent and selective fatty acid synthase (FAS, FASN) inhibitor (IC50 = 79 nM by cell-free human FAS assay) with little or no inhibitory potency toward a panel of 30 receptors & channels (<20%>10 μM). BI 99179 inhibits cellular FAS activity in vitro (IC50 = 180 nM/human H1975, 600 nM/murine hypothalamic N-42 cells) and increases hypothalamic [malonyl-CoA] in rats in vivo (2 h post 10 mg/kg or 2-24 hr post 100 mg/kg p.o.). Note: adverse effects in rats are reported at day 4 (30 mg/kg) and day 9 (3 mg/kg). |
|
| Company Name: |
SPIRO PHARMA
|
| Tel: |
|
| Website: |
www.spiropharma.com.cn |
|