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129551-91-3

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129551-91-3 Structure

129551-91-3 Structure
IdentificationBack Directory
[Name]

JM 221
[CAS]

129551-91-3
[Synonyms]

JM 221
[Molecular Formula]

C8H14Cl2O4Pt.C6H13N.H3N
[MOL File]

129551-91-3.mol
[Molecular Weight]

556.387
Hazard InformationBack Directory
[Description]

JM-221 is a novel platinum(IV) dicarboxylate complex exhibiting enhanced cytotoxicity in human ovarian carcinoma cell line when compared to Cisplatin. Comparison with platinum accumulation from Cisplatin suggests that the increased cytotoxicity of JM-221 may be related_x000D_ to increased accumulation within the cell. JM-221 is more lipophilic than Cisplatin, which may account for improved uptake in Cisplatin resistant cells.
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