| Identification | Back Directory | [Name]
Ro 25-6981 (Maleate) | [CAS]
1312991-76-6 | [Synonyms]
[R-(R*,S*)]-α-(4-Hydroxyphenyl)-β-methyl-4-(phenylmethyl)-1-piperidinepropanol maleate salt
1-Piperidinepropanol, α-(4-hydroxyphenyl)-β-methyl-4-(phenylmethyl)-, ( αR,βS)-, (2Z)-2-butenedioate (1:1) | [Molecular Formula]
C26H33NO6 | [MDL Number]
MFCD06798375 | [MOL File]
1312991-76-6.mol | [Molecular Weight]
455.543 |
| Chemical Properties | Back Directory | [storage temp. ]
2-8°C | [solubility ]
H2O: soluble2mg/mL (clear solution, warmed) | [form ]
powder | [color ]
white to beige | [optical activity]
[α]/D +15 to +22°, c = 1 in methanol |
| Hazard Information | Back Directory | [Uses]
Ro 25-6981 maleate is a potent NMDA receptor antagonist. | [Definition]
ChEBI: Ro 25-6981 maleate is the maleic acid salt of Ro 25-6981. It is a potent and selective antagonist of GluN2B-containing NMDA receptors. It has a role as an anticonvulsant, an antidepressant, a neuroprotective agent and a NMDA receptor antagonist. It contains a Ro 25-6981(1+). | [Biochem/physiol Actions]
Ro 25-6981 maleate salt is a potent and selective antagonist of NMDA glutamate receptors containing the NR2B subunit with IC50 values of .009 μM for NR2B vs. 52 μM for NR2A subunits. Ro 25-6981 has been shown to have neuroprotectant effects and to reduce inflammatory and neuropathic pain in rodent models. | [storage]
Store at -20°C |
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