| Identification | Back Directory | [Name]
12-((6-Deoxyhexopyranosyl)oxy)-1,10-dihydroxy-8-methyl-6H-benzo(d)naph tho(1,2-b)pyran-6-one | [CAS]
132417-97-1 | [Synonyms]
BE 12406B
12-((6-Deoxyhexopyranosyl)oxy)-1,10-dihydroxy-8-methyl-6H-benzo(d)naph tho(1,2-b)pyran-6-one
1,10-Dihydroxy-8-methyl-12-[(6-deoxy-α-L-mannopyranosyl)oxy]-6H-benzo[d]naphtho[1,2-b]pyran-6-one
6H-Benzo[d]naphtho[1,2-b]pyran-6-one, 12-[(6-deoxy-α-L-mannopyranosyl)oxy]-1,10-dihydroxy-8-methyl- | [Molecular Formula]
C24H22O9 | [MDL Number]
MFCD00894481 | [MOL File]
132417-97-1.mol | [Molecular Weight]
454.429 |
| Hazard Information | Back Directory | [Uses]
BE-12406B is an antitumor agent that can be found in the culture broth of a streptomycete. BE-12406B can inhibit the growth of Vincristine (HY-N0488)-resistant or Doxorubicin (HY-15142A)-resistant P388 murine leukemia cell lines as well as their parent sensitive cell line[1][2]. | [References]
[1] Nakajima S, et, al. New antitumor substances, BE-12406A and BE-12406B, produced by a streptomycete. II. Structure determination. J Antibiot (Tokyo). 1991 Oct;44(10):1061-4. DOI:10.7164/antibiotics.44.1061
[2] Kojiri K, et, al. New antitumor substances, BE-12406A and BE-12406B, produced by a streptomycete. I. Taxonomy, fermentation, isolation, physico-chemical and biological properties. J Antibiot (Tokyo). 1991 Oct;44(10):1054-60. DOI:10.7164/antibiotics.44.1054 |
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