| Identification | Back Directory | [Name]
XILVEPYQJIOVNB-ZEJCXXMWSA-N | [CAS]
1329837-73-1 | [Synonyms]
XILVEPYQJIOVNB-ZEJCXXMWSA-N | [Molecular Formula]
C18H14D4F3NO4 | [MDL Number]
MFCD34567904 | [MOL File]
1329837-73-1.mol | [Molecular Weight]
373.36 |
| Hazard Information | Back Directory | [Uses]
Medication used to alleviate joint and muscle pain. | [Biological Activity]
Etofenamate-d4 is intended for use as an internal standard for the quantification of etofenamate by GC- or LC-MS. Etofenamate is a non-steroidal anti-inflammatory drug (NSAID) and diethylene glycol ester form of flufenamic acid that has anti-inflammatory and analgesic activities.1,2 It inhibits lipoxygenase isolated from guinea pig leukocytes (IC50 = 5.3 μM) and the production of prostaglandin E2 in stimulated rat peritoneal macrophages.2 In vivo, etofenamate reduces acetic acid-induced vascular permeability in mice and UV-induced erythema in guinea pigs in a dose-dependent manner at doses ranging from 40-320 and 5-20 mg/kg, respectively.1 Etofenamate (40 mg/kg per day for 21 days) inhibits inflammation in a rat model of adjuvant-induced arthritis. It also decreases the pain response in a silver nitrate-induced rat model of arthritis and the acetic acid-induced writhing test in mice, indicating analgesic activity. Formulations containing etofenamate have been used in the treatment of osteoarthritis. | [References]
1.Nakamura, H., Motoyoshi, S., Imazu, C., et al.Anti-inflammatory, analgesic and anti-pyretic activities of a non-steroidal anti-inflammatory drug, etofenamate, in experimental animalsNihon Yakurigaku Zasshi.80(2)125-135(1982)
2.Nakamura, H., Motoyoshi, S., Ishii, K., et al.The mode of anti-inflammatory action of a topical non-steroidal anti-inflammatory drug, etofenamateNihon Yakurigaku Zasshi.89(1)15-24(1987)
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Energy Chemical
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021-58432009 400-005-6266 |
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http://www.energy-chemical.com |
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ChemeGen 中国
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18818260767 |
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https://www.chemegen.com |
| Company Name: |
Pharma Affiliates
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172-5066494 |
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https://www.chemicalbook.com/ShowSupplierProductsList694812/0.htm |
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