| Identification | Back Directory | [Name]
ASARININ | [CAS]
133-04-0 | [Synonyms]
ASARININ
L-Asarinin
EPI-SESAMIN
(-)-SESAMINE
(-)-ASARININ
ASARININ(RG)(SEE SESAMIN)
Asarinin, 98%, from Aristolochia debilis Sieb. & Zucc.
5,5'-[(1R,3aα,4S,6aα)-Tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diyl]bis(1,3-benzodioxole)
5-[4-(1,3-benzodioxol-5-yl)-1,3,3a,4,6,6a-hexahydrofuro[3,4-c]furan-1-yl]-1,3-benzodioxole
(-)-5,5'-[(1R,3aα,4S,6aα)-Tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diyl]bis[1,3-benzodioxole] | [Molecular Formula]
C20H18O6 | [MDL Number]
MFCD00198067 | [MOL File]
133-04-0.mol | [Molecular Weight]
354.35 |
| Chemical Properties | Back Directory | [Melting point ]
121° | [alpha ]
D20 -118.6°; D23 -122° (chloroform) | [Boiling point ]
504.4±50.0 °C(Predicted) | [density ]
1.385±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C Freezer | [solubility ]
Chloroform (Slightly), DMSO (Slightly, Sonicated) | [form ]
Solid | [color ]
White to Off-White |
| Hazard Information | Back Directory | [Description]
Asarinin is a lignan that has been found in A. sieboldii.1 It is an epimer of sesamin (Item No. 70310) and a noncompetitive inhibitor of Δ5-desaturase (Ki = 0.28 mM).2 It is selective for Δ5-desaturase over Δ6- and Δ9-desaturase. Asarinin is cytotoxic to A2780 and SKOV3 ovarian cancer cells (IC50s = 38.45 and 60.87 μM, respectively) but not immortalized ovarian surface epithelial cells (IC50 = >200 μM).1 It induces apoptosis and activates caspase-3, -8, and -9 in A2780 and SKOV3 cells. | [Uses]
l-Asarinin in combination with pellitorine is a potential larvicides for the control of insecticide-resistant mosquito populations. Possesses antimicrobial activity. | [target]
IL Receptor | IFN-γ | CXCR | TLR |
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