| Identification | Back Directory | [Name]
4-Thiazolecarboxaldehyde, 2-(1-methylethyl)- (9CI) | [CAS]
133047-46-8 | [Synonyms]
2-isopropylthiazol-4-carbaldehyde
2-isopropylthiazole-4-carbaldehyde
2-(1-methylethyl)-4-Thiazolecarboxaldehyde
2-(propan-2-yl)-1,3-thiazole-4-carbaldehyde
4-Thiazolecarboxaldehyde, 2-(1-methylethyl)-
4-Thiazolecarboxaldehyde, 2-(1-methylethyl)- (9CI) | [EINECS(EC#)]
604-604-1 | [Molecular Formula]
C7H9NOS | [MDL Number]
MFCD06660125 | [MOL File]
133047-46-8.mol | [Molecular Weight]
155.22 |
| Chemical Properties | Back Directory | [Boiling point ]
232.4±13.0 °C(Predicted) | [density ]
1.159±0.06 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2-8°C | [pka]
1.10±0.10(Predicted) | [InChI]
InChI=1S/C7H9NOS/c1-5(2)7-8-6(3-9)4-10-7/h3-5H,1-2H3 | [InChIKey]
NUEZKCPTDMEROB-UHFFFAOYSA-N | [SMILES]
S1C=C(C=O)N=C1C(C)C |
| Hazard Information | Back Directory | [Synthesis]
A solution of 3.1 g (15.6 mmol) of ethyl 2-isopropylthiazole-4-carboxylate in 50 ml of dichloromethane was cooled under N2 atmosphere to -78° C and treated dropwise with 15.6 ml (23.4 mmol) of a 1.5 M solution of diisobutylaluminum hydride in toluene over 1.5 h. After being stirred for an additional 0.5 h, the solution was quenched with 5 ml of methanol followed by 15 ml of aqueous Rochelle's salt. The resulting mixture was partitioned between chloroform and aqueous Rochelle's salt, dried over Na2SO4, and concentrated to provide 1.37 g (56 %) of the crude 4-Formyl-2-isopropylthiazole. |
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