| Identification | Back Directory | [Name]
tert-Butyl N-[4-(2-chloroacetamido)butyl]carbamate | [CAS]
133264-58-1 | [Synonyms]
Chloroacetamido-C4-NHBoc
tert-Butyl N-[4-(2-chloroacetamido)butyl]carbamate
Carbamic acid, N-[4-[(2-chloroacetyl)amino]butyl]-, 1,1-dimethylethyl ester | [Molecular Formula]
C11H21ClN2O3 | [MDL Number]
MFCD24452363 | [MOL File]
133264-58-1.mol | [Molecular Weight]
264.75 |
| Hazard Information | Back Directory | [Biological Activity]
Chloroacetamido-C4-NHBoc is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. | [References]
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
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