| Identification | Back Directory | [Name]
PAGOCLONE | [CAS]
133737-32-3 | [Synonyms]
Ip 456
CI-1043
AGOCLONE
Rp 62955
RP 59037
(+)-RP-59037; IP-456; RP-62955; CI-1043
2-(7-Chloro-1,8-naphthyridin-2-yl)-3-(5-methyl-2-oxohexyl)-1-isoindolinone
2-(7-Chloro-1,8-naphthyridin-2-yl)-3-(5-Methyl-2-oxohexyl)isoindolin-1-one | [EINECS(EC#)]
225-799-5 | [Molecular Formula]
C23H22ClN3O2 | [MDL Number]
MFCD00864700 | [MOL File]
133737-32-3.mol | [Molecular Weight]
407.899 |
| Chemical Properties | Back Directory | [Boiling point ]
582.1±50.0 °C(Predicted) | [density ]
1.273±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
1.62±0.30(Predicted) | [color ]
White to off-white | [InChI]
InChI=1S/C23H22ClN3O2/c1-14(2)7-10-16(28)13-19-17-5-3-4-6-18(17)23(29)27(19)21-12-9-15-8-11-20(24)25-22(15)26-21/h3-6,8-9,11-12,14,19H,7,10,13H2,1-2H3 | [InChIKey]
HIUPRQPBWVEQJJ-UHFFFAOYSA-N | [SMILES]
C1(=O)C2=C(C=CC=C2)C(CC(=O)CCC(C)C)N1C1=CC=C2C(=N1)N=C(Cl)C=C2 |
| Hazard Information | Back Directory | [Description]
Pagoclone is a drug that belongs to the class of cyclopyrrolones. It binds to the benzodiazepine binding site on GABAA receptors and acts as a negative allosteric modulator, thereby enhancing the inhibitory effects of GABA and reducing neuronal excitability. | [Uses]
Anti-anxiety agent. | [Application]
Pagoclone has been shown to have anti-inflammatory properties in an animal model of inflammatory bowel disease and may be useful for the treatment of this condition. | [Brand name]
Bextra (Interneuron). |
|
|