| Identification | Back Directory | [Name]
Nattokinase | [CAS]
133876-92-3 | [Synonyms]
NattoLife
Natokonase
Nattokinase
Nattokinease
Nattoesse Haruno-Ogawa
NATTOKINASE 20,000 FIP
Nattokinase (peptidolytic)
Nattokinase extract：Nattoesse extract
Liposomal NATTOKINASE, NATTOKINASE NanoEmulsion, NanoActive NATTOKINASE, Oil-Soluble NATTOKINASE
4-(Carboxymethyl)-2-[(1R)-1-{[N-(2,5-dichlorobenzoyl)glycyl]amino}-3-methylbutyl]-6-oxo-1,3,2-dioxaborinane-4-carboxylic acid
4-(carboxymethyl)-2-[(1R)-1-[[2-[(2,5-dichlorobenzoyl)amino]acetyl]amino]-3-methylbutyl]-6-oxo-1,3,2-dioxaborinane-4-carboxylic
4-(carboxymethyl)-2-[(1R)-1-[[2-[(2,5-dichlorobenzoyl)amino]acetyl]amino]-3-methylbutyl]-6-oxo-1,3,2-dioxaborinane-4-carboxylic acid | [EINECS(EC#)]
229-880-6 | [Molecular Formula]
N/A | [MOL File]
133876-92-3.mol | [Molecular Weight]
517.122 |
| Chemical Properties | Back Directory | [form ]
Solid | [color ]
White to off-white | [InChIKey]
YTXSYWAKVMZICI-VVSYKVCONA-N | [SMILES]
O1C(=O)CC(CC(O)=O)(C(O)=O)OB1[C@@H](NC(CNC(=O)C1=CC(Cl)=CC=C1Cl)=O)CC(C)C |&1:14,r| |
| Hazard Information | Back Directory | [Chemical Properties]
Nattokinase is an enzyme (a protein that speeds up biochemical reactions) that is extracted from a popular Japanese food called natto. Natto is boiled soybeans that have been fermented with a bacterium called Bacillus natto. | [Uses]
Although nattokinase is promoted for use as a fibrinolytic and thrombolytic agent, clinical trials are lacking to support such use. There is also no substantial evidence that nattokinase lowers blood pressure in hypertension. | [Mechanism of action]
Nattokinase decreases the ability of blood to clot. This "thins the blood" and might protect against conditions caused by blood clots such as stroke, heart attack, and others. | [Side effects]
Small, short-term trials evaluating nattokinase reported no adverse reactions. There is a theoretical risk of bleeding, based on a case report of acute cerebellar hemorrhage in a patient with a history of ischemic stroke. Thrombosis was reported after substitution of nattokinase for warfarin in a patient with a mechanical aortic valve. Rare cases of late-onset anaphylaxis with natto have been attributed to poly-gamma-glutamic acid, a product of the fermentation process that may be present in nattokinase supplements. |
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