| Identification | Back Directory | [Name]
Amfepramone hydrochloride | [CAS]
134-80-5 | [Synonyms]
tenuate
Anfamon
Tenapil
Moderatan
tenuate-dospan
tenuatehydrochloride
regenonhydrochloride
amfepramonhydrochloride
Amfepramone Hydrocloride
amfepramone hydrochloride
amphepramonumhydrochloride
Diethylproion hydrochloride
diethylpropionehydrochloride
DIETHYLPROPION HYDROCHLORIDE
DIETHYLPROPIONHYDROCHLORIDE,USP
Diethylcathinone (hydrochloride)
amfepramone hydrochloride tablets
a-Benzoyltriethylammonium Chloride
α-Benzoyl triethyl ammonium chloride
alpha-benzoyltriethylammoniumchloride
alpha-benzoyltriethylaminehydrochloride
2-(diethylamino)-propiophenonhydrochloride
Diethylpropion Hydrochloride CIV (200 mg)
Diethylpropion hydrochloride solution
2-(DIETHYLAMINO)PROPIOPHENONE HYDROCHLORIDE
1-phenyl-2-diethylaminopropanone-1hydrochloride
1-phenyl-2-diethylamino-1-propanonehydrochloride
2-(diethylamino)-1-phenyl-1-propanonhydrochloride
DIETHYLPROPION HYDROCHLORIDE SYMPATHOMIM ETIC, ANOR
2-(Diethylamino)-1-phenyl-1-propanone Hydrochloride
AMFEPRAMONE HYDROCHLORIDE (DIETHYLPROPION HYDROCHLORIDE)
1-Propanone,2-(diethylaMino)-1-phenyl-, hydrochloride (1:1) | [EINECS(EC#)]
205-156-5 | [Molecular Formula]
C13H20ClNO | [MDL Number]
MFCD00058013 | [MOL File]
134-80-5.mol | [Molecular Weight]
241.76 |
| Chemical Properties | Back Directory | [Appearance]
Off-White Solid | [Melting point ]
180-1810C | [Fp ]
9℃ | [storage temp. ]
Controlled Substance, -20°C Freezer | [solubility ]
DMF: 1.25 mg/ml; DMSO: 3 mg/ml; Ethanol: 3 mg/ml; Methanol: 1 mg/ml; PBS (pH 7.2): 10 mg/ml | [form ]
A crystalline solid |
| Hazard Information | Back Directory | [Chemical Properties]
Off-White Solid | [Uses]
Controlled substance (stimulant). Anorexic. | [Definition]
ChEBI: The hydrochloride salt of diethylpropion. A central stimulant and indirect-acting sympathomimetic, it is an appetite depressant and is used as an anoretic in the short term management of obesity. | [Originator]
Tenuate,Merrell National ,US,1959 | [Manufacturing Process]
1,145 g of α-bromopropiophenone and 850 g of diethylamine are combined
under stirring and heated on a water bath to boiling. The precipitate is filtered
off under suction and washed with benzol. The filtrate is shaken up with
aqueous hydrogen chloride, the aqueous solution made alkaline and etherified.
The solution freed of the ether is fractionated. The boiling point (6 mm) is
140°C and the yield 800 g. The base is dissolved in acetic ester and
precipitated with isopropanolic hydrogen chloride. After suction filtration and
washing with ether the yield is found to be 750 g (80%)and the melting point
168°C. | [Therapeutic Function]
Anorexic | [General Description]
Because it has two large (relative to H or methyl) N-alkylsubstituents, diethylpropion hydrochloride, 1-phenyl-2-diethylaminopropan-1-one hydrochloride (Tenuate, Tepanil),has fewer sympathomimetic, cardiovascular, and CNSstimulatoryeffects than amphetamine. It is reportedly ananorexiant agent that can be used for the treatment of obesityin patients with hypertension and cardiovascular disease.According to the generalization long used for thisgroup of drugs, increasing N-alkyl size reduces central 1effects and increases β effects, even though the effects arelikely mediated principally by indirect NE release. |
|