| Identification | Back Directory | [Name]
BETA-GLYCEROL PHOSPHATE DISODIUM SALT | [CAS]
13408-09-8 | [Synonyms]
β-Glycerophosphate
Sodium B Glycerophosphate
Disodium β-glycerol phosphate
trichloromethyl carbonochloridate
beta-Glycerophosphate, 200mM soln
Sodium--glycerophosphate, GR 99%+
β-Glycerol phosphate disodium salt
Two sodiuMglycerophosphatefivewater
BETA-GLYCEROPHOSPHATE DISODIUM SALT
BETA-GLYCEROL PHOSPHATE DISODIUM SAL
BETA-GLYCEROL PHOSPHATE DISODIUM SALT
BETA- LYCEROL PHOSPHATE DISODIUM SALT
SODIUM B-GLYCEROPHOSPHATE PENTAHYDRATE
sodium á-glycerophosphate pentahydrate
SODIUM SS-GLYCEROPHOSPHATE PENTAHYDRATE
BLUE DUO PROTEIN MARKER, LOW RANGE BIOT
Disodium β-Glycerophosphate Pentahydrate
β-Glycerophosphate (sodium salt hydrate)
Disodium β-Glycerophosphate Pentahydrate
SodiuM 1,3-dihydroxypropan-2-yl phosphate
Disodiumβ-GlycerophosphatePentahydrate>
chlorocarbonic acid trichloromethyl ester
DisodiuM β-glycerol phosphate pentahydrate
disodium 2-(phosphonatooxy)propane-1,3-diol
β-Glycerophosphate disodium salt pentahydrate
beta-Glycerophosphate disodium salt 5-hydrate
.beta.-Glycerophosphate (sodium salt hydrate)
Disodium beta-glycerol phosphate pentahydrate
á-glycerol phosphate disodium salt pentahydrate
β-Glycerol phosphate disodium salt pentahydrate
-β-Glycerol Phosphate Disodium Salt Pentahydrate
b-Glycerophosphate disodium salt pentahydrate 97+%
β-glycerophosphoric acid disodium salt pentahydrate
β-Glycerol phosphate pentahydrate disodium salt
beta-Glycerophosphoric acid disodium salt pentahydrate
SodiuM 1,3-dihydroxypropan-2-yl phosphate pentahydrate
beta-Glycerophosphate, disodium salt pentahydrate, max. 2% alpha
Disodiumβ-GlycerophosphatePentahydrate[forBiochemicalResearch]>
DisodiuM β-Glycerophosphate Pentahydrate [for BiocheMical Research]
DisodiuM beta-Glycerophosphate Pentahydrate [for BiocheMical Research]
β-Glycerol phosphate disodium salt pentahydrate,Disodium β-glycerol phosphate
Disodium β-glycerol phosphate
Glycerol 2-Phosphate Disodium Salt
β-Glycerophosphoric Acid Disodium Salt | [EINECS(EC#)]
639-414-7 | [Molecular Formula]
C3H7Na2O6P | [MDL Number]
MFCD00149083 | [MOL File]
13408-09-8.mol | [Molecular Weight]
216.037 |
| Chemical Properties | Back Directory | [Melting point ]
>300°C | [storage temp. ]
2-8°C
| [solubility ]
H2O: 0.1 g/mL, clear, colorless
| [form ]
White powder | [color ]
Whiteto Off-White | [Water Solubility ]
Soluble in water. | [Merck ]
14,8622 | [BRN ]
3744328 | [InChIKey]
PEMUISUYOHQFQH-UHFFFAOYSA-L |
| Hazard Information | Back Directory | [Description]
β-Glycerophosphate is a protein phosphatase inhibitor that acts as a phosphate group donor in matrix mineralization studies.1,2,3 It promotes bone matrix mineralization when delivered to osteoblasts by providing a source of phosphate ions.1 β-Glycerophosphate (10 mM) accelerates calcification of cultured vascular smooth muscle cells through an alkaline phosphatase-related mechanism.4 | [Chemical Properties]
Solid | [Uses]
β-Glycerol Phosphate was shown to have promoted mineralization in vitro by modulating bone cell metabolic activity and/or serving as a local source of inorganic phosphate ions. | [General Description]
A phosphate group donor in matrix mineralization studies. Accelerates calcification in vascular smooth muscle cells. Also acts as a protein phosphatase inhibitor. | [Biochem/physiol Actions]
Beta-Glycerophosphate is a classical serine-threonine phosphatase inhibitor used in kinase reaction buffers. BGP is often used in combination with other phosphatase/protease inhibitors for broad spectrum inhibition. It functions as an organic phosphate donor and has been used in culture media for mesenchymal stem cell differentiation to osteoblast-type cells. BGP is also used to buffer M17 media for Lactococcus culture in recombinant protein expression | [Purification Methods]
Crystallise it from water. [Attwood et al. Biochem J 253 389 1988, Beilstein 1 IV 2766.] | [References]
[1]. chung ch, golub ee, forbes e, et al. mechanism of action of beta-glycerophosphate on bone cell mineralization. calcif tissue int. 1992 oct;51(4):305-11.
[2]. fujimoto h, mabuchi i. isolation of cleavage furrows from eggs of regular sea urchins and identification of furrow-specific proteins. j biochem. 1997 sep;122(3):518-24.
[3]. lecanda f, avioli lv, cheng sl. regulation of bone matrix protein expression and induction of differentiation of human osteoblasts and human bone marrow stromal cells by bone morphogenetic protein-2. j cell biochem. 1997 dec 1;67(3):386-96.
[4]. shioi a, nishizawa y, jono s, et al. beta-glycerophosphate accelerates calcification in cultured bovine vascular smooth muscle cells. arterioscler thromb vasc biol. 1995 nov;15(11):2003-9. |
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