ChemicalBook--->CAS DataBase List--->1345808-25-4

1345808-25-4

1345808-25-4 Structure

1345808-25-4 Structure
IdentificationBack Directory
[Name]

Arginase inhibitor 1
[CAS]

1345808-25-4
[Synonyms]

Arginase inhibitor 1
1-Piperidinebutanoic acid, α-amino-α-(4-boronobutyl)-, (αR)-
(alphaR)-alpha-Amino-alpha-(4-boronobutyl)-1-piperidinebutanoic acid
[Molecular Formula]

C13H27BN2O4
[MDL Number]

MFCD28167713
[MOL File]

1345808-25-4.mol
[Molecular Weight]

286.18
Chemical PropertiesBack Directory
[Boiling point ]

523.0±60.0 °C(Predicted)
[density ]

1.147±0.06 g/cm3(Predicted)
[storage temp. ]

Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
[solubility ]

DMSO: 50 mg/ml; Water: 30 mg/ml
[form ]

Powder
[pka]

2.22±0.44(Predicted)
[color ]

White to gray
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319-H335
[Precautionary statements ]

P261-P305+P351+P338
Hazard InformationBack Directory
[Description]

Arginase inhibitor 1 is an inhibitor of arginase I and II (IC50s = 223 and 509 nM, respectively, for the recombinant human enzymes). It decreases arginase I activity in CHOK cells expressing human arginase I (IC50 = 8 μM). Arginase inhibitor 1 (100 mg/kg, i.v.) reduces infarct size in a rat model of myocardial ischemia and reperfusion injury induced by left-main coronary artery occlusion.
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