| Identification | Back Directory | [Name]
WSMXIQXWHPSVDE-WHAUHWDVSA-N | [CAS]
1350636-82-6 | [Synonyms]
BC-3781 ACETATE
Lefamulin acetate
BC-3781;BC 3781;BC3781
WSMXIQXWHPSVDE-WHAUHWDVSA-N
Lefamulin acetate (BC-3781 acetate)
WSMXIQXWHPSVDE-WHAUHWDVSA-N USP/EP/BP | [EINECS(EC#)]
208-388-5 | [Molecular Formula]
C30H49NO7S | [MDL Number]
MFCD28963990 | [MOL File]
1350636-82-6.mol | [Molecular Weight]
567.78 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMSO:100.0(Max Conc. mg/mL);176.12(Max Conc. mM) | [form ]
Solid | [color ]
White to off-white | [InChIKey]
WSMXIQXWHPSVDE-IHBHSJRLNA-N | [SMILES]
C(=O)(O)C.C[C@H]1[C@@H]([C@](C[C@@H](OC(=O)CS[C@@H]2CC[C@@H](N)C[C@H]2O)C2([C@H](C)CCC31CCC(=O)[C@]32[H])C)(C)C=C)O |&1:5,6,7,9,15,18,21,24,33,r| |
| Hazard Information | Back Directory | [Chemical Properties]
Lefamulin acetate is a white to off-white solid. It is a stable compound (requiring no special storage conditions) which is highly soluble in water and 0.9% sodium chloride solution (>300mg/ml). The hydration level of lefamulin acetate at ambient conditions is typically below 1% w/w.
| [Uses]
Lefamulin (BC-3781) acetate is an orally active antibiotic. Lefamulin acetate inhibits protein synthesis by binding to the peptidyl transferase center of the 50S bacterial ribosome. Lefamulin acetate has anti-inflammatory activity. Lefamulin acetate can be used in the research of bacterial infections, such as bacterial pneumonia.
| [Definition]
Lefamulin acetate is a single stereoisomer semi-synthetically derived from pleuromutilin, a homochiral, natural fermentation product of known absolute stereochemistry. Lefamulin acetate is a diastereomer with R-configuration at carbons of the cyclohexane moiety. The absolute configuration of the active substance has been confirmed by single-crystal structure determination.
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