| Identification | Back Directory | [Name]
1H-Indole-2-carboxylic acid, 3-(2-amino-1-cyanoethenyl)-6,7-dichloro-1-methyl-, ethyl ester | [CAS]
1354448-60-4 | [Synonyms]
KH-CB20
1H-Indole-2-carboxylic acid, 3-(2-amino-1-cyanoethenyl)-6,7-dichloro-1-methyl-, ethyl ester | [Molecular Formula]
C15H13Cl2N3O2 | [MOL File]
1354448-60-4.mol | [Molecular Weight]
338.19 |
| Chemical Properties | Back Directory | [Boiling point ]
604.1±55.0 °C(Predicted) | [density ]
1.39±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 100 mg/mL (295.69 mM; Need ultrasonic) | [form ]
Solid | [pka]
1.70±0.70(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Biological Activity]
KH-CB20, an E/Z mixture, is a potent and selective inhibitor of CLK1 and the closely related isoform CLK4, with an IC50 of 16.5 nM for CLK1. KH-CB20 can also inhibit DYRK1A (IC50=57.8 nM) and CLK3 (IC50=488 nM)[1].
KH-CB20 shows selectivity for CLK1 (IC50=16.5 nM) over DYRK1A (IC50=57.8 nM) and CLK3 (IC50=488 nM)[1]. | [References]
[1]. Fedorov O, et, al. Specific CLK inhibitors from a novel chemotype for regulation of alternative splicing. Chem Biol. 2011 Jan 28;18(1):67-76. |
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