| Identification | Back Directory | [Name]
NS-018 (maleate) | [CAS]
1354799-87-3 | [Synonyms]
NS-018 (maleate)
Ilginatinib maleate
NS018 MALEATE;ILGINATINIB MALEATE
ILGINATINIB (MALEATE) (NS-018 (MALEATE)) | [Molecular Formula]
C25H24FN7O4 | [MOL File]
1354799-87-3.mol | [Molecular Weight]
505.501 |
| Hazard Information | Back Directory | [Biological Activity]
Ilginatinib maleate (NS-018 maleate) is a highly potent, orally available JAK2 inhibitor with IC50 of 0.72 nM, 46-fold selectivity for JAK1 (IC50, 33 nM) and 54-fold for JAK3 ( IC50, 39 nM), and 22 times that of Tyk2 (IC50, 22 nM). | [in vivo]
Ilginatinib maleate (NS-018 maleate) (12.5, 25, 50, 100 mg/kg, p.o.) potently prolongs the survival of mice and reduces splenomegaly in a mouse Ba/F3-JAK2V617F disease model. | [target]
| JAK2 0.72 nM (IC 50 ) | Tyk2 22 nM (IC 50 ) | JAK1 33 nM (IC 50 ) | JAK3 39 nM ( IC 50 ) | | [storage]
Store at -20°C |
|
| Company Name: |
Musechem
|
| Tel: |
+1-800-259-7612 |
| Website: |
www.musechem.com |
| Company Name: |
DC Chemicals
|
| Tel: |
021-58447131 13564518121 |
| Website: |
https://www.chemicalbook.com/ShowSupplierProductsList927327/0.htm |
|