| Identification | Back Directory | [Name]
URB937 | [CAS]
1357160-72-5 | [Synonyms]
URB937
3'-Carbamoyl-6-hydroxybiphenyl-3-yl cyclohexylcarbamate
Cyclohexylcarbamic acid 3′–carbamoyl–6–hydroxybiphenyl–3–yl ester
Carbamic acid, N-cyclohexyl-, 3'-(aminocarbonyl)-6-hydroxy[1,1'-biphenyl]-3-yl ester | [EINECS(EC#)]
604-604-1 | [Molecular Formula]
C20H22N2O4 | [MDL Number]
MFCD22987960 | [MOL File]
1357160-72-5.mol | [Molecular Weight]
354.4 |
| Chemical Properties | Back Directory | [Boiling point ]
562.8±50.0 °C(Predicted) | [density ]
1.31±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
DMSO: soluble15mg/mL, clear | [form ]
powder (1:1 ratio of product to ethanol) | [pka]
9.08±0.50(Predicted) | [color ]
white to beige |
| Hazard Information | Back Directory | [Uses]
URB 937 is a potent inhibitor of fatty-acid amide hydrolase (FAAH), an intracellular serine hydrolase responsible for the deactivation of the endocannabinoid anandamide. It is actively extruded from t
he central nervous system (CNS), and therefore increases anandamide levels exclusively in peripheral tissues. | [Biological Activity]
URB937 is a fatty acid amide hydrolase (FAAH) inhibitor th at is actively excluded from the CNS by the membrane transporter ABCG2. The ED50 for inhibition of FAAH activity in the brain is 200 times higher than inhibition of renal FAAH activity. In vivo administration of URB937 elevates anandamide levels in peripheral tissuesand attenuates acetic acid-induced writhinghyperalgesia in a sciatic nerve ligation modeland pain and edema in carrageenan injected paws. |
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| Company Name: |
BOC Sciences
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| Tel: |
16314854226 |
| Website: |
www.bocsci.com |
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