| Identification | Back Directory | [Name]
4(1H)-Quinolinone, 8-chloro-2-[(2,4-dichlorophenyl)amino]-3-(3-methyl-1-oxobutyl)-5-nitro- | [CAS]
1361227-90-8 | [Synonyms]
JH-RE-06
4(1H)-Quinolinone, 8-chloro-2-[(2,4-dichlorophenyl)amino]-3-(3-methyl-1-oxobutyl)-5-nitro- | [Molecular Formula]
C20H16Cl3N3O4 | [MOL File]
1361227-90-8.mol | [Molecular Weight]
468.72 |
| Chemical Properties | Back Directory | [Boiling point ]
586.9±50.0 °C(Predicted) | [density ]
1.503±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 5 mg/mL (10.67 mM) | [form ]
Solid | [pka]
-3.78±0.70(Predicted) | [color ]
White to yellow |
| Hazard Information | Back Directory | [Biological Activity]
JH-RE-06 is a potent and selective inhibitor of REV1-REV7 interaction th at induces REV1 dimerization blocking the REV1-REV7 interaction and POL ϲ recruitment. JH-RE-06 potently inhibits translesion synthesis (TLS) and augments cisplatin effectiveness in cultured human and mouse cell lines. It improves effectiveness of cisplatin in A375 tumor xenograft mouse model. |
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