| Identification | Back Directory | [Name]
2-[1.1-dimethyl ethyl ethoxy carbonyl]amino-3-nitro benzoic acid ethyl ester | [CAS]
136285-65-9 | [Synonyms]
Azilsartan impurity Z
Candesartan ester intermediate C3
Ethyl 2-[(t-butoxycarbonyl)amino]-3-nitrobenzoate
Ethyl 2-((tert-butoxycarbonyl)amino)-3-nitrobenzoate
Ethyl-2-(tertiary butoxy carbonyl aMino)-3-nitro benzoate
ETHYL-2-T-BUTOXY-2-CARBOXYLAMINO-3-NITROBENZOATE 136285-65-9
Ethyl 2-((((2-methylpentan-2-yl)oxy)carbonyl)amino)-3-nitrobenzoate
2-[[(1,1-Dimethylethoxy)carbonyl]amino]-3-nitrobenzoic acid ethyl ester
Benzoicacid, 2-[[(1, 1-diMethylethoxy)carbonyl]aMino]-3-nitro-, ethyl ester
2-[1.1-dimethyl ethyl ethoxy carbonyl]amino-3-nitro benzoic acid ethyl ester
2-[1.1-diMethyl ethyl ethoxy carbonyl]aMino-3-nitro benzoic acid Ethyl Ester ( C3 ) | [Molecular Formula]
C16H22N2O6 | [MDL Number]
MFCD28142772 | [MOL File]
136285-65-9.mol | [Molecular Weight]
338 |
| Hazard Information | Back Directory | [Acquired resistance]
A mixture of ethyl 2-carboxy-3-nitrobenzoate(23.9 g) and thionyl chloride (12 ml) in benzene (150 ml) was heated under reflux for 3 hours. The reaction mixture was concentrated to dryness. The resultant acid chloride (26 g, quantitative) was dissolved in methylene chloride (20 ml). The solution was added dropwise to a mixture of sodium azide (9.75 g) in dimethylformamide(DMF) (20 ml) while stirring vigorously. The reaction mixture was poured into ether-hexane (3:1, 200 ml) and water (250 ml) to separate into two layers. The organic layer was washed with water and then dried, followed by evaporation of the solvent. The residue was dissolved in t-butanol (200 ml), and the solution was heated gradually with stirring, followed by heating under reflux for 2 hours. The reaction mixture was concentrated in vacuo to give an oily product Ethyl 2-((tert-butoxycarbonyl)amino)-3-nitrobenzoate (30 g). |
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