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ChemicalBook--->CAS DataBase List--->1362911-19-0

1362911-19-0

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1362911-19-0 Structure

1362911-19-0 Structure
IdentificationBack Directory
[Name]

proTAME
[CAS]

1362911-19-0
[Synonyms]

proTAME
pro-Tosyl-L-Arginine Methyl Ester
[Molecular Formula]

C34H38N4O12S
[MDL Number]

MFCD32671680
[MOL File]

1362911-19-0.mol
[Molecular Weight]

726.75
Chemical PropertiesBack Directory
[density ]

1.32±0.1 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

DMSO: Soluble
[form ]

Solid
[pka]

7.05±0.46(Predicted)
[color ]

White to off-white
Safety DataBack Directory
[Signal word ]

Warning
[Hazard statements ]

H227
[Precautionary statements ]

P210-P280-P370+P378-P403+P235-P501
Hazard InformationBack Directory
[Description]

ProTAME is an inhibitor of both APC/CFzr and APC/CCdc20. Combinations of proTAME with topoisomerase inhibitors, etoposide and doxorubicin, significantly increase cell death in Multiple Myeloma (MM) cell lines and primary cells, particularly if TOPIIα levels are first increased through pre-treatment with ProTAME.
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