ChemicalBook--->CAS DataBase List--->136381-85-6

136381-85-6

136381-85-6 Structure

136381-85-6 Structure
IdentificationBack Directory
[Name]

SR27897
[CAS]

136381-85-6
[Synonyms]

SR27897
SR 27897 hydrate
{2-[4-(2-Chloro-phenyl)-thiazol-2-ylcarbamoyl]-indol-1-yl}-acetic acid
2-[[[4-(2-Chlorophenyl)-2-thiazolyl]amino]carbonyl]-1H-indole-1-aceticacid
1H-Indole-1-acetic acid,2-[[[4-(2-chlorophenyl)-2-thiazolyl]amino]carbonyl]-
2-[[[4-(2-chlorophenyl)-2-thiazolyl]amino]carbonyl]-1H-indole-1-acetic acid hydrate
[Molecular Formula]

C20H14ClN3O3S
[MDL Number]

MFCD21608519
[MOL File]

136381-85-6.mol
[Molecular Weight]

411.86
Chemical PropertiesBack Directory
[density ]

1.49±0.1 g/cm3(Predicted)
[storage temp. ]

Desiccate at +4°C
[solubility ]

DMSO: ≥10mg/mL at warmed to 60°C
[form ]

powder
[pka]

4.00±0.10(Predicted)
[color ]

white to tan
Safety DataBack Directory
[Hazard Codes ]

T
[Risk Statements ]

25-41
[Safety Statements ]

26-45
[RIDADR ]

UN 2811 6.1 / PGIII
[WGK Germany ]

3
Hazard InformationBack Directory
[Uses]

SR 27897 is a human cholecystokinin type 1 (CCK1) competitive antagonist.
[Definition]

ChEBI: 2-[2-[[[4-(2-chlorophenyl)-2-thiazolyl]amino]-oxomethyl]-1-indolyl]acetic acid is an indolyl carboxylic acid.
[Biological Activity]

Potent, non-peptide CCK 1 receptor antagonist that displays > 33-fold selectivity over CCK 2 receptors (EC 50 values are 6 and 200 nM respectively). Causes an increase in plasma leptin levels and increases food intake in rats in vivo .
[storage]

Store at -20°C
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