| Identification | Back Directory | [Name]
25 MG CALPAIN INHIBITOR IIRESEARCH GRADE | [CAS]
136632-32-1 | [Synonyms]
ALLM (Calpain Inhibitor)
ALLM (Ac-Leu-Leu-Met-CHO)
Calpain Inhibitor II, ALLM
N-acetyl-Leu-Leu-methional
Calpain Inhibitor II powder
ALLM (Calpain Inhibitor) 95% purity
25 MG CALPAIN INHIBITOR IIRESEARCH GRADE
CALPAIN INHIBITOR II (N-AC-LEU-LEU METHIORINAL) | [EINECS(EC#)]
603-969-3 | [Molecular Formula]
C19H35N3O4S1 | [MDL Number]
MFCD00065506 | [Molecular Weight]
401.56 |
| Chemical Properties | Back Directory | [storage temp. ]
−20°C | [solubility ]
Soluble in ethanol at 20mg/ml | [form ]
powder | [color ]
white | [BRN ]
7693643 | [Stability:]
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month. |
| Hazard Information | Back Directory | [Description]
ALLM (136632-32-1) is a cell-permeable, peptide aldehyde inhibitor of calpain (calpain I, Ki?= 120 nM, calpain II, Ki?= 230 nM) and other neutral cysteine proteases. Potent inhibitor of cathepsin L (Ki=0.6 nM) and cathepsin B (Ki=100 nM).1?Weak inhibitor of the chymotrypsin-like activity of the proteasome.2?Cell permeable. | [Uses]
ALLM (Calpain Inhibitor) is a cell-permeable, peptide aldehyde inhibitor of calpain I and calpain II. ALLM acts as a very potent inhibitor of cathepsin L and the strongest inhibitor of cathepsin B amongst the peptide aldehydes. This compound inhibits the processing of malaria aspartic hemoglobinases plasmepsins I and II?in vitro. ALLM also inhibits other neutral cysteine proteases, and activation-induced programmed cell death. It restores defective immune responses in HIV+ donors. ALLM blocks nitric oxide production by activated macrophages by interfering with transcription of the inducible nitric oxide synthase gene. ALLM also acts as a weak inhibitor of proteasome. | [Uses]
Calpain inhibitor II is a cell-permeable peptide that restricts the activity of calpain, cathepsin L and cathepsin B. Calpain inhibitor II also prevents the methylmercury-induced cell death of cultured rat cerebellar neurons. | [Definition]
ChEBI: (2S)-2-acetamido-4-methyl-N-[4-methyl-1-[[4-(methylthio)-1-oxobutan-2-yl]amino]-1-oxopentan-2-yl]pentanamide is a peptide. | [References]
1) Sasaki?et al.?(1990),?Inhibitory effect of di- and tripeptidyl aldehydes on calpains and cathepsins;?J. Enzyme Inhib.,?3?195
2) Vinitsky?et al.?(1992),?Inhibition of the chymotrypsin-like activity of the pituitary multicatalytic proteinase complex; Biochemistry,?31?9421 |
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