| Identification | Back Directory | [Name]
2-(1-Phenyl-cyclopropylamino)-pyrimidine-5-carboxylic acid hydroxyamide | [CAS]
1375465-91-0 | [Synonyms]
ACY-738
CS-2244
ACY 738; ACY738
ACY738;ACY-738;ACY 738
2-(1-phenylcyclopropylamino)-N-hydroxypyrimidine-5-carboxamide
N-Hydroxy-2-[(1-phenylcyclopropyl)amino]-5-pyrimidinecarboxamide
5-Pyrimidinecarboxamide, N-hydroxy-2-[(1-phenylcyclopropyl)amino]-
2-(1-Phenyl-cyclopropylamino)-pyrimidine-5-carboxylic acid hydroxyamide | [Molecular Formula]
C14H14N4O2 | [MDL Number]
MFCD28347706 | [MOL File]
1375465-91-0.mol | [Molecular Weight]
270.29 |
| Chemical Properties | Back Directory | [density ]
1.433±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO:32.0(Max Conc. mg/mL);118.39(Max Conc. mM) | [form ]
A crystalline solid | [pka]
7.75±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
ACY-738 is an inhibitor of histone deacetylase 6 (HDAC6; IC50 = 1.7 nM).1 It is selective for HDAC6 over HDAC1-3 (IC50s = 94, 128, and 218 nM, respectively). ACY-738 (5 mg/kg) increases acetylation of α-tubulin in mouse brain. It increases exploratory activity in a novel open-field test and reduces immobility time in a tail suspension test in wild-type, but not neural cell-selective HDAC6 knockout, mice when administered at a dose of 50 mg/kg, indicating anxiolytic and antidepressant-like activity, respectively. ACY-738 (100 mg/kg in the diet) attenuates decreases in caudal nerve sensory nerve action potential (SNAP) amplitude and increases in hind paw mechanical hypersensitivity in a mouse model of peripheral neuropathy induced by vincristine (Item No. 11764).2 It decreases hepatorenal cystogenesis in a rat model of polycystic liver disease when administered at a dose of 30 mg/kg.3 | [storage]
Store at -20°C |
|
|