| Identification | Back Directory | [Name]
2-[1-(3-Fluoro-phenyl)-cyclohexylamino]-pyrimidine-5-carboxylic acid hydroxyamide | [CAS]
1375466-18-4 | [Synonyms]
ACY-77
ACY-775
CS-2821
ACY-775
(ACY 775
ACY-775; ACY 775; ACY775.
5-Pyrimidinecarboxamide, 2-[[1-(3-fluorophenyl)cyclohexyl]amino]-N-hydroxy-
2-[1-(3-Fluoro-phenyl)-cyclohexylamino]-pyrimidine-5-carboxylic acid hydroxyamide | [Molecular Formula]
C17H19FN4O2 | [MDL Number]
MFCD30533691 | [MOL File]
1375466-18-4.mol | [Molecular Weight]
330.36 |
| Chemical Properties | Back Directory | [density ]
1.342±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Sealed in dry,2-8°C | [solubility ]
DMSO:35.33(Max Conc. mg/mL);106.94(Max Conc. mM)
DMF:20.0(Max Conc. mg/mL);60.54(Max Conc. mM)
DMF:PBS (pH 7.2) (1:4):0.2(Max Conc. mg/mL);0.61(Max Conc. mM)
Ethanol:34.5(Max Conc. mg/mL);104.43(Max Conc. mM) | [form ]
A solid | [pka]
7.74±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
ACY-775 is a novel histone deacetylase 6-selective (HDAC6) inhibitor with antidepressant and pro-cognitive properties. ACY-775 inhibits HDAC6 with low nanomolar potency and a selectivity of 60- to 1500-fold over class I HDACs. | [storage]
Store at -20°C |
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