| Identification | Back Directory | [Name]
T2-aminoalcohol hydrochloride | [CAS]
1380782-27-3 | [Synonyms]
T2AA hydrochloride
T2-aminoalcohol hydrochloride
(βS)-β-Amino-4-(4-hydroxyphenoxy)-3,5-diiodobenzenpropanol
(S)-4-(4-(2-amino-3-hydroxypropyl)-2,6-diiodophenoxy)phenol hydrochloride | [Molecular Formula]
C15H16ClI2NO3 | [MDL Number]
MFCD30182241 | [MOL File]
1380782-27-3.mol | [Molecular Weight]
547.554 |
| Hazard Information | Back Directory | [Uses]
T2AA hydrochloride has been used as a chemical inhibitor of proliferating cell nuclear antigen (PCNA) in vaccinia virus. | [Uses]
T2AA is a small molecule inhibitor of PCNA/PIP-box interactions, which suppresses translesion DNA synthesis. | [Biochem/physiol Actions]
T2AA is an inhibitor of PCNA/ PIP-Box interactions that binds to the PCNA cavity that interacts with PIP-Box sequences. Also T2AA inhibits PCNA Polδ3 interaction. T2AA inhibits de novo DNA synthesis, and in combination of cisplatin significantly increases growth inhibition in cancer cells. T2AA is a T3 analog that exhibits almost no thyroid hormone activity. | [storage]
Store at -20°C |
|
| Company Name: |
BOC Sciences
|
| Tel: |
|
| Website: |
https://www.bocsci.com |
| Company Name: |
DC Chemicals
|
| Tel: |
021-58447131 13564518121 |
| Website: |
https://www.chemicalbook.com/ShowSupplierProductsList927327/0.htm |
|