| Hazard Information | Back Directory | [Uses]
cis-5,11-Diethyl-5,6,11,12-tetrahydro-2,8-chrysenediol is a fluorescent and selective ligand that can be used to investigate the interactions between ligand and receptor of estrogen receptors (ERs) (1,2,3). cis-5,11-Diethyl-5,6,11,12-tetrahydro-2,8-chrysenediol is an ERα agonist and an ERβ antagonist. | [Definition]
ChEBI:(R,R)-5,11-diethyl-5,6,11,12-tetrahydro-2,8-chrysenediol is a carbotetracyclic compound that is 5,6,11,12-tetrahydrochrysene substituted by hydroxy groups at positions 2 and 8 and by ethyl groups at positions 5 and 11 (the 5R,11R-stereoisomer). It is an agonist of ER-alpha and antagonist of ER-beta receptors. It has a role as an estrogen receptor antagonist, an estrogen receptor agonist, a geroprotector and a neuroprotective agent. It is a carbotetracyclic compound and a polyphenol. | [Biological Activity]
Non-steroidal, selective estrogen receptor ligand; agonist at ER α receptor (K i = 9.0 nM) and antagonist at ER β receptor (K i = 3.6 nM). | [storage]
Store at -20°C |
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| Company Name: |
BOC Sciences
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| Tel: |
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| Website: |
https://www.bocsci.com |
| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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