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ChemicalBook--->CAS DataBase List--->1387090-01-8

1387090-01-8

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1387090-01-8 Structure

1387090-01-8 Structure
IdentificationBack Directory
[Name]

DYRKs-IN-1
[CAS]

1387090-01-8
[Synonyms]

DYRKs-IN-1
[Molecular Formula]

C30H30ClN7O4
[MDL Number]

MFCD32215330
[MOL File]

1387090-01-8.mol
[Molecular Weight]

588.06
Hazard InformationBack Directory
[Description]

DYRKs-IN-1 is a potent DYRKs (Dual-specificity tyrosine-phosphorylation-regulated kinases) inhibitor and has antitumor activity.
[in vitro]

From a data-mining effort, the team has discovered analogues of pyrido[2,3-d]pyrimidines as potent enantio-selective inhibitors of DYRK1B. Cells treated with a tool compound from this series showed the same cellular effects as down regulation of DYRK1B with siRNA._x000D_ _x000D_ Reference: Bioorg Med Chem Lett. 2013 Dec 15;23(24):6610-5. https://pubmed.ncbi.nlm.nih.gov/24239188/
[target]

DYRKs-IN-1 is a potent DYRKs (Dual-specificity tyrosine-phosphorylation-regulated kinases) inhibitor with IC50s of 5 nM and 8 nM for DYRK1A and DYRK1B, respectively.
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