| Identification | Back Directory | [Name]
metiazinic acid | [CAS]
13993-65-2 | [Synonyms]
Metian
Soripal
RP 16091
Novartril
Ambrunate
Soridermal
Metiazinic
metiazinic acid
(10-METHYL2-PHENOTHIAZINYL)ACETICACID
10H-Phenothiazine-2-acetic acid, 10-methyl-
(10-methyl-10H-phenothiazin-2-yl)acetic acid | [EINECS(EC#)]
237-795-0 | [Molecular Formula]
C15H13NO2S | [MDL Number]
MFCD00866023 | [MOL File]
13993-65-2.mol | [Molecular Weight]
271.33 |
| Chemical Properties | Back Directory | [Melting point ]
146℃ | [Boiling point ]
482.6±44.0 °C(Predicted) | [density ]
1.2237 (rough estimate) | [refractive index ]
1.7500 (estimate) | [pka]
4.12±0.10(Predicted) | [Water Solubility ]
31mg/L(30 ºC) |
| Hazard Information | Back Directory | [Originator]
Soripan,Specia,France,1970 | [Definition]
ChEBI: Phenothiazine substituted at nitrogen by a methyl group and at C-2 by a carboxymethyl group. | [Manufacturing Process]
10-Methyl-3-acetylphenthiazine is prepared in accordance with G. Cauquil and
A. Casadevall, Bull. Soc.Chim., p 768 (1955). (10-Methyl-3-phenthiazinyl)acetic acid (MP 146°C; 21.4 g) is prepared by Willgerodt's
reaction (action of sulfur and morpholine, followed by hydrolysis) employing
10-methyl-3-acetylphenthiazine as starting material. | [Therapeutic Function]
Antiinflammatory | [Trade name]
Roimal (Kantoishi, Japan),
Soripal (Torii, Japan). | [Synthesis]
Metiazinic acid is prepared via
the Willgerodt reaction (sulfur and morpholine)
from 2-acetyl-10-methylphenothiazine.
 | [Dosage]
Metiazinic acid has been beneficial to arthritis patients when given at a daily dose of
0.75 – 1.5 g/d. |
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| Company Name: |
Specs
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| Tel: |
+31 15 251 8111 |
| Website: |
www.specs.net |
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