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1400876-94-9

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1400876-94-9 Structure

1400876-94-9 Structure
IdentificationBack Directory
[Name]

JAK-IN-3
[CAS]

1400876-94-9
[Synonyms]

JAK-IN-3
JAK-IN-3 (COMPOUND 22)
[Molecular Formula]

C18H20N4O3
[MDL Number]

MFCD31813914
[MOL File]

1400876-94-9.mol
[Molecular Weight]

340.38
Chemical PropertiesBack Directory
[density ]

1.39±0.1 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[form ]

Solid
[pka]

12.70±0.50(Predicted)
[color ]

Light brown to brown
Hazard InformationBack Directory
[Biological Activity]

JAK-IN-3 (compound 22) is a potent JAK inhibitor, with IC50 values of 3 nM, 5 nM, 34 nM and 70 nM for JAK3, JAK1, TYK2 and JAK2, respectively[1].
[storage]

Store at -20°C
[References]

[1]. Spergel SH, et al. Discovery of a JAK1/3 Inhibitor and Use of a Prodrug To Demonstrate Efficacy in a Model of Rheumatoid Arthritis. ACS Med Chem Lett. 2019 Feb 13;10(3):306-311.
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