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141286-78-4

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141286-78-4 Structure

141286-78-4 Structure
IdentificationBack Directory
[Name]

2,6-DIFLUORO-4-[2-(PHENYLSULFONYLAMINO)E
[CAS]

141286-78-4
[Synonyms]

2-[2,6-Difluoro-4-[[2-[(phenylsulfonyl)amino]ethyl]thio]phenoxy]acetamide
2,6-Difluoro-4-[2-(phenylsul-fonyl-amino)-ethyl-thio]-phenoxy-acet-amide (PEPA)
[Molecular Formula]

C16H16F2N2O4S2
[MDL Number]

MFCD04974493
[MOL File]

141286-78-4.mol
[Molecular Weight]

402.44
Chemical PropertiesBack Directory
[storage temp. ]

protect from light
[solubility ]

DMSO: >20mg/mL
[form ]

solid
[color ]

white
[InChIKey]

GTACSIONMHMRPD-UHFFFAOYSA-N
Safety DataBack Directory
[WGK Germany ]

3
Hazard InformationBack Directory
[Uses]

PEPA is an allosteric potentiator of AMPA desensitization.
[Biological Activity]

Novel allosteric potentiator of AMPA receptor desensitization. Slows the rate of onset of desensitization and potentiates steady-state equilibrium currents induced by glutamate with subunit (GluR3/4 > GluR1) and splice variant (flop > flip) selectivity. Ameliorates post-ischemic memory impairment in rats following i.v. administration.
[Biochem/physiol Actions]

2,6-Difluoro-4-[2-(phenylsul-fonyl-amino)-ethyl-thio]-phenoxy-acet-amide is a structurally novel, selective, high affinity AMPA ionotropic glutamate receptor agonist that reduces ischemia-induced performance deficits in rats.
[storage]

Store at RT
Spectrum DetailBack Directory
[Spectrum Detail]

2,6-DIFLUORO-4-[2-(PHENYLSULFONYLAMINO)E(141286-78-4)1HNMR
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