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142128-57-2

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142128-57-2 Structure

142128-57-2 Structure
IdentificationBack Directory
[Name]

Oliceridine
[CAS]

142128-57-2
[Synonyms]

(-)-KETOCONAZOLE
Ethanone, 1-[4-[4-[[(2S,4R)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]-
[Molecular Formula]

C26H28Cl2N4O4
[MOL File]

142128-57-2.mol
[Molecular Weight]

531.43
Chemical PropertiesBack Directory
[solubility ]

DMSO:33.33(Max Conc. mg/mL);62.72(Max Conc. mM)
[form ]

Solid
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

(-)-Ketoconazole along with other Ketoconazle stereoisomers can be used in pharmacological activity and biological study for inducing CYP4501A1 in human and mouse hepatoma. (-)-Ketoconazole has adverse effect as impurities contained in antifungal drug ketoconazole are potent activators of human aryl hydrocarbon receptor.
[Definition]

ChEBI: (2S,4R)-ketoconazole is a cis-1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine which dioxolane moiety has (2S,4R)-configuration. It is an enantiomer of a (2R,4S)-ketoconazole.
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