| Identification | Back Directory | [Name]
LOR-253) | [CAS]
1422826-80-9 | [Synonyms]
APTO-253
(APTO253
1H-Imidazo[4,5-f][1,10]phenanthroline, 2-(6-fluoro-2-methyl-1H-indol-3-yl)- | [Molecular Formula]
C22H14FN5 | [MOL File]
1422826-80-9.mol | [Molecular Weight]
367.38 |
| Hazard Information | Back Directory | [Description]
APTO-253 isomer is an isomer of APTO-253 with the Fluoro-atom in 6-position. APTO-253 also known as LOR-253, LT-253, is a small molecule inhibitor of human metal-regulatory transcription factor 1 (MTF-1) with potential antitumor activity. MTF-1 inhibitor LOR-253 inhibits MTF-1 activity and thereby induces the expression of MTF-1 dependent tumor suppressor factor Kruppel like factor 4 (KLF4). This subsequently leads to the downregulation of cyclin D1, blocking cell cycle progression and proliferation. This agent also causes decreased expression of genes involved in tumor hypoxia and angiogenesis. |
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