ChemicalBook--->CAS DataBase List--->142439-95-0

142439-95-0

142439-95-0 Structure

142439-95-0 Structure
IdentificationBack Directory
[Name]

Sp-Cyclic AMPS (sodium salt)
[CAS]

142439-95-0
[Synonyms]

YTUKZYORDGLGPR-BIQAKYJPSA-M
Sp-Cyclic AMPS (sodium salt)
[Molecular Formula]

C10H11N5NaO5PS
[MDL Number]

MFCD03703496
[MOL File]

142439-95-0.mol
[Molecular Weight]

367.253
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

≤25mg/ml in H2O
[form ]

crystalline solid
[color ]

White to off-white
Hazard InformationBack Directory
[Description]

Several cyclic nucleotide phosphodiesterases (PDE2, -5, -6, -10, and -11) contain a tandem of GAF domains in their N-terminal regulatory region that are thought to mediate cAMP- or cGMP-induced stimulation of adenylyl and guanylyl cyclases. Sp-cyclic AMPS (Sp-cAMPS) is a derivative of cAMP that binds the PDE10 GAF domain (EC50 = 40 μM). It has been used to study GAF-mediated stimulation of PDE10.
[References]

[1] dostmann w r, taylor s s, genieser h g, et al. probing the cyclic nucleotide binding sites of camp-dependent protein kinases i and ii with analogs of adenosine 3', 5'-cyclic phosphorothioates[j]. journal of biological chemistry, 1990, 265(18): 10484-10491.
[2] hanks s k, quinn a m, hunter t. the protein kinase family: conserved features and deduced phylogeny of the catalytic domains[j]. science, 1988, 241(4861): 42-52.
[3] spicuzza l, belvisi m g, birrell m a, et al. evidence that the anti‐spasmogenic effect of the β‐adrenoceptor agonist, isoprenaline, on guinea‐pig trachealis is not mediated by cyclic amp‐dependent protein kinase[j]. british journal of pharmacology, 2001, 133(8): 1201-1212.
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